Group leader
Cyriel Pennartz
The brain consists of billions of neurons which mediate complex cognitive processes such as memory, attention, decision-making and consciousness. How can it be that such ´mental´ operations are implemented by the electrical activity of networks of communicating neurons? How can this collective network activity be explained from electrochemical processes that direct neuronal communication at the cellular and molecular level?
In the CSN-group these general questions are elaborated in the following specific
themes of research:
The group uses a wide array of techniques to approach these questions, ranging from patch-clamp techniques in brain slices to ensemble recordings and functional magnetic resonance imaging (fMRI). In this multi-level approach we study how groups of neurons within the brain behave during learning tasks and are able to ´replay´ their experience-specific patterns of electrical activity during subsequent sleep.
Using human brain imaging and transcranial magnetic stimulation we investigate which brain structures take part in encoding, consolidation and retrieval of memories. We study how cell assemblies in the hippocampus, a structure crucial for memory of daily-life events, communicate with assemblies in ventral striatum and prefrontal cortex to exert control over formation of emotional memory and decision making.
The wiring and neurochemical modulation of these structures is investigated by patch clamp techniques and studies of transmitter release. The research lines on sensory integration and spatial representation rely on two-photon microscopy, ensemble recordings and computational modelling and focuses on the hippocampal formation and sensory neocortex. Malfunctioning of the brain structures under investigation has been implied in brain disorders such as schizophrenia, drug addiction, Alzheimer´s and Parkinson´s disease.
Luc Gentet
Francesco Battaglia
Wim Ghijsen
Silviu Rusu
Hemi Malkki
Jorrit Montijn
All portrait pictures by Els Velzing
| prof. dr. Cyriel Pennartz | |
| Francesco Battaglia, PhD | |
| Wim Ghijsen, PhD | |
| Carien Lansink, PhD | |
| Luc Gentet, PhD | |
| Laura Donga, MSc | |
| Jan Lankelma, MSc | |
| Henrique Cabral, MSc | |
| Pieter Goltstein, MSc | |
| Martin Vinck, MSc | |
| Tara Arbab, MSc | |
| Jeroen Bos, MSc | |
| Silviu Rusu, MSc | |
| Gerben Klein, MSc | |
| Jorrit Montijn MSc | |
| Zbigniew Zielinski, MSc |
Hemi A.I. Malkki, Laura A.B. Donga, Sabine E. de Groot and NeuroBSIK Mouse Phenomics Consortium,
Francesco P. Battaglia, Cyriel M.A. Pennartz (2011)
Towards mouse models of perseveration: A heritable component in extinction of operant behavior
in fourteen standard and recombinant inbred mouse lines
Neurobiology of Learning and Memory Volume 96, Issue 2, September 2011, Pages 280-287
PDF
Daselaar SM, Huijbers W, Pennartz CMA, Cabeza R, (2011)
The hippocampusis coupled with the default network during memory
retrieval but not during memory encoding PLoS ONE (in press)
Vinck M, Oostenveld R, Van Wingerden M, Battaglia FP and Pennartz CMA (2011)
An improved index of phase-synchronization for electrophysiological data in
the presence of volume-conduction, noise and sample-size bias
Neuroimage (in press)
Malkki HAI, Donga AB, de Groot SE, Battaglia FP, NeuroBSIK
Mouse Phenomics consortium and Pennartz CMA (2010)
Heritability and dissociation of traits relevant for operant conditioning in mice
Front. in Behav. Neurosci. Vol. 4, art. 171. doi: 10.3389/fnbeh.2010.00171.
abstract/PDF
Sanchez-Fibla M, Bernadet U, Wasserman E, Pelc T, Mintz M, Jackson JC,
Lansink C, Pennartz C, Verschure PFMJ (2010)
Allostatic control for robot behavior regulation : a comparative rodent-robot study.
Advances in Complex Systems 13: 377-403
abstract/PDF
Van der Meer MAA, Kalenscher T, Lansink CS, Pennartz CMA, Berke JD, Redish AD (2010)
Integrating early results on ventral striatal gamma
oscillations in the rat (invited review)
Frontiers in Neurosci. Vol. 4,
art. 28. doi: 10.3389/fnins.2010.00028.
abstract/PDF
Kalenscher T, Daselaar S, Huijbers W, Tobler P. N. and Pennartz, CMA (2010)
Neural signatures of intransitive preferences
Frontiers in Human Neurosci. doi: 10.3389/fnhum.2010.00049.
abstract/PDF
Van Wingerden M, Vinck M, Lankelma J, Battaglia FP and Pennartz CMA (2010)
Learning-associated gamma-band phase-locking of action-outcome selective
neurons in orbitofrontal cortex
abstract/PDF
Lansink CS, Goltstein PM, Lankelma JV and Pennartz CMA (2010)
Fast spiking interneurons of the rat ventral striatum : temporal coordination
of activity with principal cells and responsiveness to reward
Eur. J.Neurosci. 32: 494-508
abstract/PDF
Van Wingerden M, Vinck M, Lankelma J and Pennartz CMA (2010)
Theta-band phase-locking of orbitofrontal neurons during reward expectancy
J. Neurosci. 30: 7078-7087.
abstract/PDF
Vinck M, Van Wingerden M, Womelsdorf T, Fries P and Pennartz CMA (2010)
The pairwise phase consistency: a bias-free measure of rhythmic neuronal synchronization
Neuroimage 51: 112-122.
abstract/PDF
Daselaar, SM, Porat Y, Huijbers W, Pennartz CMA (2010)
Modality-specific and modality-independent components of the human imagery system.
Neuroimage 52: 677-685.
abstract/PDF
Daselaar SM, Huijbers W, de Jonge M, Goltstein PM, Pennartz CMA (2010)
Experience-dependent alterations in conscious resting state activity
following perceptuomotor learning
Neurobiology of Learning and Memory 93: 422-427
abstract/PDF
Tobias Kalenscher, Carien S. Lansink, Jan V. Lankelma and Cyriel M. A. Pennartz (2010)
Reward-Associated gamma oscillations in ventral striatum are regionally
differentiated and modulate local firing activity
J Neurophysiol 103: 1658-1672, 2010
abstract/PDF
Cyriel M.A. Pennartz (2009)
Identification and integration of sensory modalities : Neural basis
and relation to consciousness
Consciousness and Cognition 18 (2009) 718–739
abstract/PDF
Esther van Duuren, Geoffrey van der Plasse, Jan Lankelma, Ruud N. J. M. A. Joosten,
Matthijs G.P. Feenstra and C.M.A. Pennartz (2009)
Single-Cell and Population Coding of Expected Reward Probability
in the
Orbitofrontal Cortex of the Rat
Journal of Neuroscience, vol 29(28) : 8965-8976
abstract/PDF
Lansink CS, Goltstein PM, Lankelma JV, McNaughton BL, Pennartz CMA (2009)
Hippocampus Leads Ventral Striatum in Replay of Place-Reward Information
PLoS Biol 7(8): e1000173. doi:10.1371/journal.pbio.1000173
abstract/PDF
Peyrache A, Khamassi M, Benchenane K, Wiener S, Battaglia F (2009)
Replay of rule-learning related neural patterns in the prefrontal cortex during sleep
Nature Neuroscience, online: 31 May 2009 | doi:10.1038/nn.2337
abstract/PDF
Huijbers W, Pennartz CMA, Cabeza R, Daselaar SM (2009)
When learning and remembering compete : A functional MRI Study,
PLoS Biology 2009 Jan 13; 7(issue 1) e(1000011) page 1-7
abstract
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van Duuren E, Lankelma J, Pennartz CMA (2008)
Population coding of reward magnitude in the orbitofrontal cortex of the rat
Journal of Neuroscience, vol 28 : 8590–8603
abstract/PDF
Lansink CS, Goltstein PM, Lankelma J, Joosten RN, McNaughton B, Pennartz CMA (2008)
Preferential reactivation of motivationally relevant information in the ventral striatum
Journal of Neuroscience vol 28 : 6372-6382
abstract/PDF
T Kalenscher, CMA Pennartz, is a bird in the hand worth two in the future? (2008)
The neuroeconomics of intertemporal decision-making
Progress in Neurobiology 84, 284–315
Van Duuren E, Nieto Escámez FA, Joosten RNJMA,
Visser R, Mulder AB and Pennartz CMA (2007)
Neural coding of reward magnitude in the orbitofrontal cortex
of the rat during a five-odour olfactory discrimination task.
Learning and Memory 14: 446-456
abstract/PDF
Taverna S, Van Dongen, Y, Groenewegen, HJ, and Pennartz CMA (2004)
Direct physiological evidence for synaptic connectivity between medium-sized spiny neurons in rat nucleus accumbens in situ.
Journal of Neurophysiology (91) : 1111-1121
abstract/PDF
Voorn P, Vanderschuren LJMJ, Groenewegen HJ, Robbins TW and Pennartz CMA (2004)
Putting a spin on the dorsal-ventral divide of the striatum
Trends in Neuroscience 27 : 468-474.
Pennartz CMA, Lee E, Verheul J, Lipa P, Barnes CA and McNaughton BL (2004)
The ventral striatum in off-line processing: ensemble reactivation during sleep and modulation by hippocampal ripples
Journal of Neuroscience vol 24 : 6446-6456
abstract/PDF
Pennartz CMA, De Jeu MTG, Bos NPA, Schaap J and Geurtsen AMS (2002)
Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock.
Nature 416 : 286-290
abstract/PDF
All portrait pictures by Els Velzing This page was last updated on 20 jan 2012
